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KMID : 1189420220350010024
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2022 Volume.35 No. 1 p.24 ~ p.37
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A Study on The Manufacturing Method, Formulation and Toxicity for Clinical Use of Topical Agents in Geumgweyoryak
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You Jae-Hyun
Kim Kyu-Seok
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Abstract
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Objectives : The purpose of this literature review is to analyze process of manufacture and formulation and toxicity of Geumgweyoryak(ÐÝ?é©ÕÔ)¡¯s external applicants for modern and safe using.
Methods : This study used the Geumgweyoryak(ÐÝ?é©ÕÔ) reprinted by Zhao Kaimei(ðáËÒÚ¸) as basic data for a understanding of the manufacture and formulation and toxicity for external applicants. Among the 25 chapters, the 22 chapters were studied except for the last three chapters, which are known to be written by later writers.
Based on the above, Geumgweyoryeok(ÐÝ?é©ÕÔ)¡¯s external applicants was analyzed the process of manufacture, formulation and the toxicity.
Results : There are 11 types of external applicants of Geumgweyoryak(ÐÝ?é©ÕÔ). Washing method(á©Ûö) was used 2 times, Drop method(Õ÷Ûö) was used 1 time, Smoke method(ý·Ûö) was used 2 times, Rubbing method(ؤÛö) was used 1 time, Plaster method(ݧÛö) was used 2 times, Invading method(öÙÛö) was used 1 time, Suppository method (ñ¦Ûö) was used 2 times, Flatiron method(Õ§Ûö) was used 1 time. According to classified the modern formulation, there are 4 types of powder formulation, 4 types of liquid formulation, 2 types of suppository, and 1 type of Semi-solid formulation. Especially toxic drugs, such as Realgar(ê©üÜ) or Hydrocerussite(æçÝÏ), should be careful.
When Realgar(ê©üÜ) smokes, a toxic substance called AS2O3 can come out. Hydrocerussite(æçÝÏ) can cause lead poisoning. Lead increases the risk of anemia, dehydration, and lead neuropathy when chronically exposed.
Conclusion : We supposed that this study can serve as a basic data to help clinical Korean doctors to use the prescription for external applicants more safely and to easily apply it in the form of external applicants.
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KEYWORD
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Geumgweyoryak, External applicants, Process of manufacture, Formulation, Toxicity
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